High-Performance Thermal Cycler for PCR Applications

Introducing the GeneCycler, a high-throughput thermal cycler for PCR designed for efficient, reliable PCR thermal cycling. This water bath–based system can run up to 25 PCR plates per batch, combining ease of use with a robust, streamlined basket design for consistent results.

Genecycler PCR Instrumentation

This advanced water bath thermal cycler for PCR sets new standards in efficiency, precision, and sustainability. Unlike traditional Peltier-based thermal cyclers, it delivers faster ramp rates, uniform temperature control, and exceptional consistency across every run. By minimizing energy consumption and reducing maintenance needs, it supports both high-performance workflows and sustainable lab practices. Compared to competing PCR thermal cyclers, it not only outperforms in throughput and reliability but also provides outstanding value with lower lifetime costs, comprehensive support, and long-term operational benefits for demanding PCR applications.

Key Features

High Throughput

Run up to 20 low profile 384-well PCR plates per run or 16 standard 384- or 1536-well plates, supporting assay miniaturisation and ultra-high-throughput PCR workflows.

Energy Efficient

Uses up to 90% less energy than standard Peltier PCR blocks, reducing costs and environmental impact.

Precise Temperature Control

Three individually temperature-controlled water bath tanks.

Automated Water Management

Auto-filling and emptying of water tanks with scheduled pre-heating and shutdown.

Robust and user-friendly Design

The zero-maintenance basket design with no moving parts ensures enhanced reliability, while the intuitive touchscreen interface allows for easy setup and operation.

Broad Compatibility

Compatible with high-precision PCR microplates for rapid and precise temperature control.

Product Video

High-Throughput Thermal Cycler for PCR

The GeneCycler is a next-generation PCR thermal cycler engineered to maximize throughput, precision, and sustainability. Designed for demanding workflows, it can cycle up to 25 low-profile 384-well PCR plates or 20 standard 384-well or 1536-well plates in a single run, making it ideal for high-throughput molecular applications. Its support for 384- and 1536-well plate formats makes the GeneCycler well suited for assay miniaturisation strategies that reduce reaction volumes while increasing data output. Three individually temperature-controlled water baths (40 °C–98 °C) with ±0.1 °C accuracy ensure highly reliable and reproducible PCR thermal cycling results. 

An intuitive touchscreen interface simplifies protocol creation, editing, and real-time monitoring, while the system’s preheating function and flexible cycling modes, including standard and touchdown PCR support diverse research needs. Compared to conventional Peltier-based instruments, the GeneCycler reduces energy consumption by up to 80%, cutting operational costs while promoting sustainable lab practices. By combining advanced thermal control, exceptional capacity, and user-friendly design, this thermal cycler for PCR delivers unmatched efficiency and value. 

PCR lab services

PRODUCT SUPPORT

Our instruments are built for peak performance, durability and exceptional reliability. To ensure they continue operating at their best, we offer a range of support services – available whenever you need them.

SPARES & SUPPORT KIT

Maximise performance with tailored training and a Spares & Support Kit, designed to keep your instrument running smoothly. With first-line remote engineer access and essential spare parts, you can perform routine maintenance as required. Plus, benefit from cost savings with an exclusive discount on your Annual Contract.

ON-SITE ENGINEER SUPPORT

For advanced assistance, our expert engineers provide on-site support to keep your instrument performing at its best. With industry-leading service and rapid response times, we help you maintain efficiency and reliability when it matters most.

CONSUMABLES FOR THIS PRODUCT

384-Well PCR Plates with Slim Design

Low-volume, slim-profile PCR plates offering excellent thermal uniformity and precision for high-throughput PCR workflows.

PCR 384-Well Plate

Rigid, fully-skirted 384-well PCR plate ensuring excellent stability and uniform heating through every thermal cycle.

PCR Plate Sealing Film for 96- & 384-Well Plates

Secure, airtight PCR sealing film prevents evaporation and contamination during thermal cycling for reliable results.

Documentation

FAQ:

How does the GeneCycler compare to standard Peltier-based PCR instrumentation?

Unlike traditional Peltier-based PCR thermal cyclers, which typically process one plate per run, the GeneCycler can cycle up to 20–25 plates at once, significantly increasing throughput. It also offers quicker cycling times, more accurate temperature management, and consumes up to 80% less energy, reducing operational costs.

What are the advantages of GeneCycler over other waterbath PCR thermal cyclers?

  • Lower operational costs due to efficient energy usage.
  • Automated water tank filling, eliminating manual refills.
  • More robust basket design with no moving parts for increased durability.
  • Superior engineering and customer support, ensuring long-term reliability.
  • Ongoing product support, unlike many older models that are no longer supported.

What plate types are compatible with the GeneCycler?

The GeneCycler supports a variety of PCR plate formats, including:
• Low-profile 384-well PCR plates (up to 25 per run).
• Standard 384-well and 1536-well PCR plates (up to 20 per run).

What cycling options are available on the GeneCycler?

The instrument supports both standard PCR and touchdown PCR, offering flexibility for different experimental needs. It also features a preheating function for optimized start-up efficiency.

How does the GeneCycler reduce running costs?

With its improved heating design, the GeneCycler consumes up to 80% less energy than standard Peltier block PCR systems. This not only lowers energy costs but also enhances sustainability without compromising performance.

How does the GeneCycler ensure precise thermal cycling?

The system features three independently controlled water baths with a temperature range of 40°C–98°C and an accuracy of ±0.1°C, ensuring highly reproducible results across all wells.

End-to-end genotyping solutions

Unlock the full spectrum of genotyping possibilities with our comprehensive, modular range of instruments. Explore our end-to-end genotyping solutions and discover the perfect fit for your laboratory, ensuring efficiency and accuracy at every step.

LOW

WORKFLOW SOLUTIONS

Entry level genotyping lab workflow with manual dispensing into PCR plates run on standard Peltier thermal cycling instruments.

  • Manual pipetting

    Multi-channel pipette manual liquid handling plus Peltier PCR block cycling.

  • GeneScanner:

    High-speed PCR plate fluorescence scanning.

Medium

WORKFLOW SOLUTIONS

Balanced solution offering moderate capacity and speed, perfect for mid-sized labs with growing demands.

  • MagC 9600:

    Single plate automated extraction

  • Manual pipetting

    Multi-channel pipette manual liquid handling

  • GeneCycler:

    High-throughput water bath thermal cycler.

  • GeneScanner:

    High-speed PCR plate fluorescence scanning.

High

WORKFLOW SOLUTIONS

High-efficiency genotyping for larger labs, providing fast and reliable results with significant sample volumes.

Ultra High

WORKFLOW SOLUTIONS

Top-tier solution designed for extensive genotyping projects, ensuring maximum productivity and rapid data generation.

READY TO EXPERIENCE THE FUTURE OF LAB AUTOMATION?

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MEET OUR TEAM

Steve AsquithManaging Director
Steve began his career in the Genetics Division of GlaxoSmithKline, as part of the team establishing GSK’s high-throughput core genotyping laboratory. Steve joined KBioscience when it was first founded in 2002 and was a key driver in taking the company from a small start-up to a multi-national service laboratory, quickly growing the company’s revenue to over $7.5M p.a. Following the acquisition of Kbioscience by LGC in 2011, Steve was appointed Global Director of Operations for LGC Genomics, responsible for over 100 staff in Europe and N. America, successfully elevating the genotyping products and service business. Steve held a crucial leadership role until he left in 2016. In 2017 Steve joined forces with John Holme to create 3CR Bioscience, a new company with a mission to deliver outstanding, customer-focused genotyping products with innovation and affordability at its core.
Dr. John HolmeTechnical Director

John joined KBioscience shortly after it was founded, in 2003, and became Head of Technical Development, building the company’s genotyping and DNA extraction product portfolio and service delivery until 2011 when it was acquired by LGC. Post-acquisition, John was appointed Head of Technical Group for LGC Genomics, in charge of all Research & Development and Technical Support activities for the company. In this role John continued to build on the high-quality products and services provided to the companies growing customer base.

During the 19 years John has worked in commercial R&D, he has co-invented numerous highly successful products including PACE®, ProbeSure, KASP™, KlearKall, KlearGene, KlearAmp and KlearTaq™, creating breakthrough offerings in genotyping and extraction and generating huge revenues for the companies he has worked in. In 2017, he joined forces with Steve Asquith and started 3CR Bioscience. John is dedicated to developing outstanding, innovative genotyping products and providing the very best technical support to customers globally.

Dr. Nisha JainOperations Director

Nisha has been innovating since the start of her career at Geneform Technologies developing Iso-thermal Genotyping Technologies. Nisha joined KBioscience in 2008, as Senior R&D Scientist and key account Technical Support Scientist, developing KASP and Klearkall performance and coinventing two further versions of KASP.

Nisha has more than 15 years’ experience working in molecular biology and genotyping technologies, with extensive experience in the areas of R&D, Quality Assurance and Customer Technical Support. She has technically assisted many giants of the industry with their protocol development and troubleshooting and continues to deliver high-quality support and guidance. In 2018, Nisha joined 3CR Bioscience as Operations Director where she continues to develop PACE and ProbeSure for an increasing range of applications, and to grow 3CR Bioscience’s new product pipeline. Nisha is dedicated to developing outstanding, innovative genotyping products and providing the very best technical support to customers globally.

Nazma SaffinGeneral Manager
For 20 years Nazma Saffin has worked and gained extensive expertise within the genotyping sector. Working at Kbioscience and then LGC, she has held operational leadership posts responsible for manufacturing and laboratory services. With experience of ISO 9001 implementation, production scale up and LEAN operations, Nazma has successfully led highly profitable production departments. Joining 3CR Bioscience in 2022, Nazma is committed to delivering operational excellence.
Greig PollandAutomation and Support Manager

Greig is a hands-on automation specialist and team leader with a strong background in laboratory and industrial automation. He has spent over 25 years developing, installing, and supporting automated systems that transformed laboratory workflows. During this time, Greig worked closely with scientists and engineers to tailor automation solutions for genotyping and molecular biology, an experience that sparked his lasting passion for combining technology with practical science.

Since then, Greig has built on that foundation through leadership roles where he leads automation and support operations. He’s known for being approachable, commercially minded, and deeply committed to helping teams and customers get the best from their technology.

Whether managing a complex automation rollout or helping a customer troubleshoot in real time, Greig brings a thoughtful, collaborative approach that keeps people ,not just machines, at the centre of what he does.