PCR Thermal Cyclers

Introducing the GeneCycler - a highly efficient, high-throughput thermal cycling water bath instrument capable of running up to 25 PCR plates per run. Easy to use waterbath PCR instrumentation with robust, streamlined basket design.

Genecycler PCR Instrumentation

This advanced water bath thermal cycler sets new standards in efficiency, precision, and sustainability – outperforming traditional Peltier-based thermal cyclers and leading competitors while offering incredible value, support and cost-benefits.

Key Features

High Throughput

Run up to 20 low profile 384-well PCR plates per run or 16 standard 384- or 1536-well plates.

Energy Efficient

Uses up to 90% less energy than standard Peltier PCR blocks, reducing costs and environmental impact.

Precise Temperature Control

Three individually temperature-controlled water bath tanks.

Automated Water Management

Auto-filling and emptying of water tanks with scheduled pre-heating and shutdown.

Robust Design

Zero-maintenance basket design with no moving parts for enhanced reliability.

User-Friendly

Intuitive touchscreen interface for easy setup and operation.

Broad Compatibility

Compatible with high-precision PCR microplates for rapid and precise temperature control.

Product Video

GeneCycler: High-Efficiency PCR Thermal Cycler for Sustainable and Precise Thermal Cycling

The GeneCycler is a high-efficiency PCR thermal cycler designed to maximize throughput and  sustainability. Capable of cycling up to 25 low-profile 384-well PCR plates or 20 standard 384-well or 1536-well PCR plates per run, it offers exceptional capacity for high-throughput workflows. Equipped with three individually temperature-controlled water baths (40°C–98°C) and precise ±0.1°C accuracy, the system ensures reliable and reproducible results. The integrated touchscreen interface simplifies protocol creation and real-time monitoring. Compared to standard Peltier-based PCR instrumentation, the GeneCycler reduces energy consumption by up to 80%, significantly lowering operational costs. With its preheating function and flexible cycling options, including standard and touchdown PCR, the GeneCycler delivers efficiency, precision, and sustainability for advanced molecular applications.

PRODUCT SUPPORT

Our instruments are built for peak performance, durability and exceptional reliability. To ensure they continue operating at their best, we offer a range of support services – available whenever you need them.

SPARES & SUPPORT KIT

Maximise performance with tailored training and a Spares & Support Kit, designed to keep your instrument running smoothly. With first-line remote engineer access and essential spare parts, you can perform routine maintenance as required. Plus, benefit from cost savings with an exclusive discount on your Annual Contract.

ON-SITE ENGINEER SUPPORT

For advanced assistance, our expert engineers provide on-site support to keep your instrument performing at its best. With industry-leading service and rapid response times, we help you maintain efficiency and reliability when it matters most.

CONSUMABLES FOR THIS PRODUCT

384-Well PCR Plate

Our 384-well PCR plates have a rigid fully-skirted frame which remains stable during thermal cycling.

384-WELL SLIM PCR PLATE

Custom low volume, low profile/slim 384-well plates

PCR PLATE SEALING FILM

Heat sealing film for 96- and 384-well PCR microplates.

Documentation

FAQ:

How does the GeneCycler compare to standard Peltier-based PCR instrumentation?

Unlike traditional Peltier-based PCR thermal cyclers, which typically process one plate per run, the GeneCycler can cycle up to 20–25 plates at once, significantly increasing throughput. It also offers quicker cycling times, more accurate temperature management, and consumes up to 80% less energy, reducing operational costs.

What are the advantages of GeneCycler over other waterbath PCR thermal cyclers?

  • Lower operational costs due to efficient energy usage.
  • Automated water tank filling, eliminating manual refills.
  • More robust basket design with no moving parts for increased durability.
  • Superior engineering and customer support, ensuring long-term reliability.
  • Ongoing product support, unlike many older models that are no longer supported.

What plate types are compatible with the GeneCycler?

The GeneCycler supports a variety of PCR plate formats, including:
• Low-profile 384-well PCR plates (up to 25 per run).
• Standard 384-well and 1536-well PCR plates (up to 20 per run).

What cycling options are available on the GeneCycler?

The instrument supports both standard PCR and touchdown PCR, offering flexibility for different experimental needs. It also features a preheating function for optimized start-up efficiency.

How does the GeneCycler reduce running costs?

With its improved heating design, the GeneCycler consumes up to 80% less energy than standard Peltier block PCR systems. This not only lowers energy costs but also enhances sustainability without compromising performance.

How does the GeneCycler ensure precise thermal cycling?

The system features three independently controlled water baths with a temperature range of 40°C–98°C and an accuracy of ±0.1°C, ensuring highly reproducible results across all wells.

End-to-end genotyping solutions

Unlock the full spectrum of genotyping possibilities with our comprehensive, modular range of instruments. Explore our end-to-end genotyping solutions and discover the perfect fit for your laboratory, ensuring efficiency and accuracy at every step.

LOW

WORKFLOW SOLUTIONS

Entry level genotyping lab workflow with manual dispensing into PCR plates run on standard Peltier thermal cycling instruments.

  • Manual pipetting

    Multi-channel pipette manual liquid handling plus Peltier PCR block cycling.

  • GeneScanner:

    High-speed PCR plate fluorescence scanning.

Medium

WORKFLOW SOLUTIONS

Balanced solution offering moderate capacity and speed, perfect for mid-sized labs with growing demands.

  • H9600:

    Single plate automated extraction

  • Manual pipetting

    Multi-channel pipette manual liquid handling

  • GeneCycler:

    High-throughput water bath thermal cycler.

  • GeneScanner:

    High-speed PCR plate fluorescence scanning.

High

WORKFLOW SOLUTIONS

High-efficiency genotyping for larger labs, providing fast and reliable results with significant sample volumes.

Ultra High

WORKFLOW SOLUTIONS

Top-tier solution designed for extensive genotyping projects, ensuring maximum productivity and rapid data generation.

READY TO EXPERIENCE THE FUTURE OF LAB AUTOMATION?

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MEET OUR TEAM

Steve Asquith Managing Director
Steve began his career in the Genetics Division of GlaxoSmithKline, as part of the team establishing GSK’s high-throughput core genotyping laboratory. Steve joined KBioscience when it was first founded in 2002 and was a key driver in taking the company from a small start-up to a multi-national service laboratory, quickly growing the company’s revenue to over $7.5M p.a. Following the acquisition of Kbioscience by LGC in 2011, Steve was appointed Global Director of Operations for LGC Genomics, responsible for over 100 staff in Europe and N. America, successfully elevating the genotyping products and service business. Steve held a crucial leadership role until he left in 2016. In 2017 Steve joined forces with John Holme to create 3CR Bioscience, a new company with a mission to deliver outstanding, customer-focused genotyping products with innovation and affordability at its core.
Dr. John Holme Technical Director
John joined KBioscience shortly after it was founded, in 2003, and became Head of Technical Development, building the company’s genotyping and DNA extraction product portfolio and service delivery until 2011 when it was acquired by LGC. Post-acquisition, John was appointed Head of Technical Group for LGC Genomics, in charge of all Research & Development and Technical Support activities for the company. In this role John continued to build on the high-quality products and services provided to the companies growing customer base. During the 19 years John has worked in commercial R&D, he has co-invented numerous highly successful products including PACE®, ProbeSure, KASPâ„¢, KlearKall, KlearGene, KlearAmp and KlearTaqâ„¢, creating breakthrough offerings in genotyping and extraction and generating huge revenues for the companies he has worked in. In 2017, he joined forces with Steve Asquith and started 3CR Bioscience. John is dedicated to developing outstanding, innovative genotyping products and providing the very best technical support to customers globally.
Dr. Nisha JainOperations Director
Nisha has been innovating since the start of her career at Geneform Technologies developing Iso-thermal Genotyping Technologies. Nisha joined KBioscience in 2008, as Senior R&D Scientist and key account Technical Support Scientist, developing KASP and Klearkall performance and coinventing two further versions of KASP. Nisha has more than 15 years’ experience working in molecular biology and genotyping technologies, with extensive experience in the areas of R&D, Quality Assurance and Customer Technical Support. She has technically assisted many giants of the industry with their protocol development and troubleshooting and continues to deliver high-quality support and guidance. In 2018, Nisha joined 3CR Bioscience as Operations Director where she continues to develop PACE and ProbeSure for an increasing range of applications, and to grow 3CR Bioscience’s new product pipeline. Nisha is dedicated to developing outstanding, innovative genotyping products and providing the very best technical support to customers globally.
Nazma Saffin General Manager
For 20 years Nazma Saffin has worked and gained extensive expertise within the genotyping sector. Working at Kbioscience and then LGC, she has held operational leadership posts responsible for manufacturing and laboratory services. With experience of ISO 9001 implementation, production scale up and LEAN operations, Nazma has successfully led highly profitable production departments. Joining 3CR Bioscience in 2022, Nazma is committed to delivering operational excellence.
Jon Curtis Non-Executive Chair
After 8 years in The Royal Air Force, Jon moved to the Imperial Cancer Research Fund where he pioneered the use of ultra high-throughput genomic automation, capable of 46,000 PCRs per hour. In the 1990’s Jon joined GlaxoSmithKline, implementing a high-throughput genomics platform into their drug discovery pipeline. Whilst there he also developed acoustic mixing into compound management, becoming the gold standard across pharma. Jon developed the world’s first commercially viable 1536-well PCR plates, automated thermal & laser plate-sealer, plus automated liquid-handling & tip washing tools to reduce waste and costs. In 2002 Jon co-founded KBioscience with Phil Robinson, utilising ultra high-throughput PCR instrumentation & a suite of automation tools to create the company’s SNPline robotic platform, with a capacity of 250,000 PCRs/day. The business was underpinned by their ground-breaking patented genotyping chemistry, KASP™, which has over 10,000 scientific papers to date. In November 2022 Jon joined 3CR Bioscience acting as an advisor bringing his commercial and scientific experience to the company.